RARE-X will kick off Xcelerate RARE: A Rare Disease Open Science Data Challenge this spring. For this inaugural challenge, researchers and data scientists will work in a collaborative and competitive environment to use patient-provided data to solve research questions focused on rare pediatric neurodevelopmental diseases. We spoke about the open science data challenge with the senior director of scientific programs for RARE-X, Karmen Trzupek, chief scientific officer of the children’s tumor foundation Salvatore La Rosa, and section head of medical informatics for Genentech, Andrew Nguyen. The three discussed open science challenges, how they work, and what RARE-X hopes to accomplish through this event.